Jian Hu
Department of Biochemistry and Molecular Biology
Department of Chemistry
BCH 501A | web site | hujian1@msu.edu
- Crystallography and NMR of membrane proteins
- Zinc transporter ZIP family proteins
- Phosphatidylinositol phosphate kinase family proteins
Recent Publications
The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a
role in zinc transport.
Zhang T, Kuliyev E, Sui D, Hu J.
Biochem J (2019) Jun 28; 476(12):1791-1803.
A structural perspective on the PP-loop ATP pyrophosphatase family.
Fellner M, Hausinger RP, Hu J.
Crit Rev Biochem Mol Biol (2018) Dec; 53(6):607-622.
Nickel-pincer nucleotide cofactor.
Hausinger RP, Desguin B, Fellner M, Rankin JA, Hu J.
Curr Opin Chem Biol (2018) Dec; 47:18-23.
Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE
from Lactobacillus plantarum.
Fellner M, Rankin JA, Desguin B, Hu J, Hausinger RP.
Biochemistry (2018) Sep 25; 57(38):5513-5523.
Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires
a CTP-dependent cyclometallase.
Desguin B, Fellner M, Riant O, Hu J, Hausinger RP, Hols P, Soumillion P.
J Biol Chem (2018) Aug 10; 293(32):12303-12317.
Structural insights into lethal contractural syndrome type 3 (LCCS3) caused by a missense
mutation of PIP5Kγ.
Zeng X, Uyar A, Sui D, Donyapour N, Wu D, Dickson A, Hu J.
Biochem J (2018) Jul 26; 475(14):2257-2269.
Selenoprotein S inhibits inflammation-induced vascular smooth muscle cell calcification.
Ye Y, Bian W, Fu F, Hu J, Liu H.
J Biol Inorg Chem (2018) Jul; 23(5):739-751.
Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the
transport pathway.
Zhang T, Liu J, Fellner M, Zhang C, Sui D, Hu J.
Sci Adv (2017) Aug; 3(8):e1700344.
Structural insights into the catalytic mechanism of a sacrificial sulfur insertase
of the N-type ATP pyrophosphatase family, LarE.
Fellner M, Desguin B, Hausinger RP, Hu J.
Proc Natl Acad Sci U S A (2017) Aug 22; 114(34):9074-9079.
Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming
Enzyme: Substrate Binding Creates a Twist.
Martinez S, Fellner M, Herr CQ, Ritchie A, Hu J, Hausinger RP.
J Am Chem Soc (2017) Aug 30; 139(34):11980-11988.