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Jian Hu

Department of Biochemistry and Molecular Biology
Department of Chemistry

BCH 501A | web site |

  • Crystallography and NMR of membrane proteins
  • Zinc transporter ZIP family proteins
  • Phosphatidylinositol phosphate kinase family proteins

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Recent Publications

The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport.
Zhang T, Kuliyev E, Sui D, Hu J.
Biochem J (2019) Jun 28; 476(12):1791-1803.

A structural perspective on the PP-loop ATP pyrophosphatase family.
Fellner M, Hausinger RP, Hu J.
Crit Rev Biochem Mol Biol (2018) Dec; 53(6):607-622.

Nickel-pincer nucleotide cofactor.
Hausinger RP, Desguin B, Fellner M, Rankin JA, Hu J.
Curr Opin Chem Biol (2018) Dec; 47:18-23.

Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum.
Fellner M, Rankin JA, Desguin B, Hu J, Hausinger RP.
Biochemistry (2018) Sep 25; 57(38):5513-5523.

Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.
Desguin B, Fellner M, Riant O, Hu J, Hausinger RP, Hols P, Soumillion P.
J Biol Chem (2018) Aug 10; 293(32):12303-12317.

Structural insights into lethal contractural syndrome type 3 (LCCS3) caused by a missense mutation of PIP5Kγ.
Zeng X, Uyar A, Sui D, Donyapour N, Wu D, Dickson A, Hu J.
Biochem J (2018) Jul 26; 475(14):2257-2269.

Selenoprotein S inhibits inflammation-induced vascular smooth muscle cell calcification.
Ye Y, Bian W, Fu F, Hu J, Liu H.
J Biol Inorg Chem (2018) Jul; 23(5):739-751.

Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway.
Zhang T, Liu J, Fellner M, Zhang C, Sui D, Hu J.
Sci Adv (2017) Aug; 3(8):e1700344.

Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Fellner M, Desguin B, Hausinger RP, Hu J.
Proc Natl Acad Sci U S A (2017) Aug 22; 114(34):9074-9079.

Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist.
Martinez S, Fellner M, Herr CQ, Ritchie A, Hu J, Hausinger RP.
J Am Chem Soc (2017) Aug 30; 139(34):11980-11988.